If it's a reference to the family, Les Beauxhommes, do you still not pronounce the -s?
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Unless it's spelled Beauxhommès, I would intuitively not pronounce the final -s. However, note that there's no pronounciation rule for last names.
Also, unlike English, if the original name doesn't have a final -s, putting one when referring to the family is not correct. The family of Dominique Dupont is Les Dupont, not Les Duponts, whereas Homer Simpson's family is referred to as The Simpsons.