We developed a professional Information System for a contracting company using MS SQL Server as a database and ... MS Access as a user interface. It includes more than 300 transactional screens, 175 reports and dashboards, does fantastic things like multi-countries payroll management, and it works pretty well, thank you! That gave us the opportunity to build a set of development tools (down to a basic but efficient source control tool) that allowed us to bring to the final users normalized, bullet-proof screens and transactions in a matter of hours.
Incidentally, we had to acquire an extensive knowledge around subjects such as VBA, Office Integration, MS-SQL, database synchronization, database migration, reporting tools, ActiveX, etc.
Depending on the moment, I do have other professional activities, where I have been hired on consultancies as an agriculture policy and development expert (my original academic training), or recruited as an independent board member for a mid-sized international company.